Claudia Angela Michela Wheeler-Kingshott, PhD
Senior Lecturer in Magnetic Resonance Physics

NMR Research Unit
Department of Neuroinflammation
Institute of Neurology
University College London
Queen Square
London WC1N 3BG

tel.: 0207 8373611 x4301
email: c.wheeler-kingshott@ion.ucl.ac.uk

Current interests:

• Quantitative MRI in the Central Nervous System;
• Applications to Multiple Sclerosis, Psychosis and Epilepsy;
• Applications at 1.5T and 3T;
• Multi nuclear spectroscopy and imaging.

In particular:

• Diffusion Tensor Imaging with applications to optic nerve, spinal cord and brain;
• Brain and spinal cord Spectroscopy and Chemical Shift Imaging;
• Magnetisation Transfer in the brain, optic nerve and spinal cord; 
• Cortical thickness;
• Relaxometry in the central nervous system;
• Functional imaging in the spinal cord.

Vacancies

Currently we are welcoming applications for a PhD position in Physics to develop functional imaging in the spinal cord, starting September 2010, funded by the ISRT. Details available on request.

Book chapters:

CAM Wheeler-Kingshott, GJ Barker, S Steens, M van Buchem.
“D- the Diffusion of Water”.
Chapter 7 in “Quantitative Magnetic Resonance in the Brain“, John Wiley $ Sons, Inc. 2003

CAM Wheeler-Kingshott.
“Novel Measurements of Diffusion in the Central Nervous System.”
Chapter 10, “Magnetic Resonance”, in “Physics and Engineering in Medicine in the New Millennium”, IPEM publications 2000

Publication list:

Kolappan M, Henderson AP, Jenkins TM, Wheeler-Kingshott CA, Plant GT,
Thompson AJ, Miller DH.
Assessing structure and function of the afferent visual pathway in multiple
sclerosis and associated optic neuritis.
J Neurol. 2009;256(3):305-19.

Wheeler-Kingshott CA, Cercignani M.
About “axial” and “radial” diffusivities.
Magn Reson Med. 2009 27;61(5):1255-1260. 

Dowell NG, Jenkins TM, Ciccarelli O, Miller DH, Wheeler-Kingshott CA.
Contiguous-slice zonally oblique multislice (CO-ZOOM) diffusion tensor imaging:
examples of in vivo spinal cord and optic nerve applications.
J Magn Reson Imaging. 2009;29(2):454-60. 

Rashid W, Hadjiprocopis A, Davies G, Griffin C, Chard D, Tiberio M, Altmann D,
Wheeler-Kingshott C, Tozer D, Thompson A, Miller DH.
Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis
with diffusion tensor imaging.
J Neurol. 2008;255(3):390-7. 

Yogarajah M, Powell HW, Parker GJ, Alexander DC, Thompson PJ, Symms MR, Boulby
P, Wheeler-Kingshott CA, Barker GJ, Koepp MJ, Duncan JS.
Tractography of the parahippocampal gyrus and material specific memory impairment in
unilateral temporal lobe epilepsy.
Neuroimage. 2008;40(4):1755-64. 

Schmierer K, Wheeler-Kingshott CA, Tozer DJ, Boulby PA, Parkes HG, Yousry TA,
Scaravilli F, Barker GJ, Tofts PS, Miller DH.
Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation.
Magn Reson Med. 2008;59(2):268-77

Ciccarelli O, Wheeler-Kingshott CA, McLean MA, Cercignani M, Wimpey K, Miller DH, Thompson AJ.
Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis.
Brain. 2007 Aug;130(Pt 8):2220-31.

Powell HW, Parker GJ, Alexander DC, Symms MR, Boulby PA, Wheeler-Kingshott CA Barker GJ, Koepp MJ, Duncan JS.
Abnormalities of language networks in temporal lobe epilepsy.
Neuroimage. 2007 May 15;36(1):209-21. Epub 2007 Feb 28.

Schmierer K, Wheeler-Kingshott CA, Boulby PA, Scaravilli F, Altmann DR, Barker GJ, Tofts PS, Miller DH.
Diffusion tensor imaging of post mortem multiple sclerosis brain.
Neuroimage. 2007 Apr 1;35(2):467-77. Epub 2006 Dec 16.

Wheeler-Kingshott CA, Trip SA, Symms MR, Parker GJ, Barker GJ, Miller DH.
In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls.
Magn Reson Med. 2006 Aug;56(2):446-51.

Powell HW, Parker GJ, Alexander DC, Symms MR, Boulby PA, Wheeler-Kingshott CA, Barker GJ, Noppeney U, Koepp MJ, Duncan JS.
Hemispheric asymmetries in language-related pathways: a combined functional MRI and tractography study.
Neuroimage. 2006 Aug 1;32(1):388-99. Epub 2006 May 2.

Ciccarelli O, Toosy AT, Marsden JF, Wheeler-Kingshott CM, Miller DH, Matthews PM, Thompson AJ.
Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis.
J Neurol. 2006 Jul;253(7):882-91. Epub 2006 Apr 20.

Samson RS, Wheeler-Kingshott CA, Symms MR, Tozer DJ, Tofts PS.
A simple correction for B1 field errors in magnetization transfer ratio measurements.
Magn Reson Imaging. 2006 Apr;24(3):255-63. Epub 2005 Dec 27.

Trip SA, Wheeler-Kingshott C, Jones SJ, Li WY, Barker GJ, Thompson AJ, Plant GT, Miller DH.
Optic nerve diffusion tensor imaging in optic neuritis.
Neuroimage. 2006 Apr 1;30(2):498-505. Epub 2005 Oct 20.

Powell HW, Parker GJ, Alexander DC, Symms MR, Boulby PA, Wheeler-Kingshott CA, Barker GJ, Koepp MJ, Duncan JS.
MR tractography predicts visual field defects following temporal lobe resection.
Neurology. 2005 Aug 23;65(4):596-9.

Diehl B, Symms MR, Boulby PA, Salmenpera T, Wheeler-Kingshott CA, Barker GJ, Duncan JS.
Postictal diffusion tensor imaging.
Epilepsy Res. 2005 Jul;65(3):137-46.

Ciccarelli O, Toosy AT, Marsden JF, Wheeler-Kingshott CM, Sahyoun C, Matthews PM, Miller DH, Thompson AJ.
Identifying brain regions for integrative sensorimotor processing with ankle movements.
Exp Brain Res. 2005 Sep;166(1):31-42. Epub 2005 Jul 21.

Ciccarelli O, Toosy AT, Hickman SJ, Parker GJ, Wheeler-Kingshott CA, Miller DH, Thompson AJ.
Optic radiation changes after optic neuritis detected by tractography-based group mapping.
Hum Brain Mapp. 2005 Jul;25(3):308-16.

Hickman SJ, Wheeler-Kingshott CA, Jones SJ, Miszkiel KA, Barker GJ, Plant GT, Miller DH.
Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis.
AJNR Am J Neuroradiol. 2005 Apr;26(4):951-6.

Parker GJ, Luzzi S, Alexander DC, Wheeler-Kingshott CA, Ciccarelli O, Lambon Ralph MA.
Lateralization of ventral and dorsal auditory-language pathways in the human brain.
Neuroimage. 2005 Feb 1;24(3):656-66.

Toosy AT, Ciccarelli O, Parker GJ, Wheeler-Kingshott CA, Miller DH, Thompson AJ.
Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging.
Neuroimage. 2004 Apr;21(4):1452-63.

Steens SC, Admiraal-Behloul F, Schaap JA, Hoogenraad FG, Wheeler-Kingshott CA, le Cessie S, Tofts PS, van Buchem MA.
Reproducibility of brain ADC histograms.
Eur Radiol. 2004 Mar;14(3):425-30.

Ciccarelli O, Toosy AT, Parker GJ, Wheeler-Kingshott CA, Barker GJ, Miller DH, Thompson AJ.
Diffusion tractography based group mapping of major white-matter pathways in the human brain.
Neuroimage. 2003 Aug;19(4):1545-55.

Guye M, Parker GJ, Symms M, Boulby P, Wheeler-Kingshott CA, Salek-Haddadi A, Barker GJ, Duncan JS.
Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo.
Neuroimage. 2003 Aug;19(4):1349-60.

Parker GJ, Haroon HA, Wheeler-Kingshott CA.
A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements.
J Magn Reson Imaging. 2003 Aug;18(2):242-54.

Davies GR, Ramani A, Dalton CM, Tozer DJ, Wheeler-Kingshott CA, Barker GJ, Thompson AJ, Miller DH, Tofts PS.
Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?
Mult Scler. 2003 Jun;9(3):246-9.

Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM.
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging.
Nat Neurosci. 2003 Jul;6(7):750-7.

Ciccarelli O, Werring DJ, Barker GJ, Griffin CM, Wheeler-Kingshott CA, Miller DH, Thompson AJ.
A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging–evidence of Wallerian degeneration.
J Neurol. 2003 Mar;250(3):287-92.

Ciccarelli O, Parker GJ, Toosy AT, Wheeler-Kingshott CA, Barker GJ, Boulby PA, Miller DH, Thompson AJ.
From diffusion tractography to quantitative white matter tract measures: a reproducibility study.
Neuroimage. 2003 Feb;18(2):348-59.

Eriksson SH, Symms MR, Rugg-Gunn FJ, Boulby PA, Wheeler-Kingshott CA, Barker GJ, Duncan JS, Parker GJ.
Exploring white matter tracts in band heterotopia using diffusion tractography.
Ann Neurol. 2002 Sep;52(3):327-34.

Parker GJ, Wheeler-Kingshott CA, Barker GJ.
Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging.
IEEE Trans Med Imaging. 2002 May;21(5):505-12.

Wheeler-Kingshott CA, Hickman SJ, Parker GJ, Ciccarelli O, Symms MR, Miller DH, Barker GJ.
Investigating cervical spinal cord structure using axial diffusion tensor imaging.
Neuroimage. 2002 May;16(1):93-102.

Parker GJ, Stephan KE, Barker GJ, Rowe JB, MacManus DG, Wheeler-Kingshott CA, Ciccarelli O, Passingham RE, Spinks RL, Lemon RN, Turner R.
Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography.
Neuroimage. 2002 Apr;15(4):797-809.

Wheeler-Kingshott CA, Parker GJ, Symms MR, Hickman SJ, Tofts PS, Miller DH, Barker GJ.
ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-suppressed ZOOM-EPI.
Magn Reson Med. 2002 Jan;47(1):24-31.

Ciccarelli O, Werring DJ, Wheeler-Kingshott CA, Barker GJ, Parker GJ, Thompson AJ, Miller DH.
Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations.
Neurology. 2001 Apr 10;56(7):926-33.

Wheeler-Kingshott CA, Thomas DL, Lythgoe MF, Guilfoyle D, Williams SR, Doran SJ.
Burst excitation for quantitative diffusion imaging with multiple b-values.
Magn Reson Med. 2000 Nov;44(5):737-45.

Wheeler-Kingshott CA, Crémillieux Y, Doran SJ.
Burst imaging: rotation artifacts and how to correct them.
J Magn Reson. 2000 Mar;143(1):161-71.

Crémillieux Y, Wheeler-Kingshott CA, Briguet A, Doran SJ.
STEAM-Burst: a single-shot, multi-slice imaging sequence without rapid gradient switching.
Magn Reson Med. 1997 Oct;38(4):645-52.